Imaging hydrogen peroxide in Alzheimer’s disease via cascade signal amplification
نویسندگان
چکیده
منابع مشابه
Imaging hydrogen peroxide in Alzheimer’s disease via cascade signal amplification
In brains of Alzheimer's disease (AD), reactive oxygen species (ROS) levels are significantly higher than that of healthy brains. Evidence suggests that, during AD onset and progression, a vicious cycle revolves around amyloid beta (Aβ) production, aggregation, plaque formation, microglia/immunological responses, inflammation, and ROS production. In this cycle, ROS species play a central role, ...
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BACKGROUND High sensitivity of analysis is constantly in demand in biomedical research and clinical diagnosis. In recent years aptamer-based analytical methods have been developed for protein detection. We developed a cascade signal amplification strategy based on molecular switches and aptamers to improve protein detection. METHODS Our cascade signal amplification strategy based on molecular...
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Plants have evolved complex regulatory mechanisms in adapting to various environmental stresses. One of the consequences of many stresses is an increase in the cellular concentration of reactive oxygen species (ROS), which are subsequently converted to hydrogen peroxide (H 2 O 2 ). An oxidative burst caused by biotic or abiotic stress leads to a disturbance in the cellular redox balance and is ...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2016
ISSN: 2045-2322
DOI: 10.1038/srep35613